Investigational • Chemotherapy is under clinical evaluation, and a variety of drugs have been found to be useful in patients who have residual or recurrent disease following surgery or radiation therapy . The combination of cisplatin + doxorubicin + vincristine + Cytoxan produced a 91 percent response rate (47 percent complete) in one study. • In one trial, almost half of the patients treated with a four-drug combination of vincristine + Cytoxan + lomustine + prednisone had complete responses. The combination of cisplatin + Adriamycin + Cytoxan has produced a 70 percent remission rate.